Best answer: Why are cancer stem cells drug resistance?


Why are cancer stem cells drug resistant?

The HIF1α signaling pathway also promotes drug resistance in CSCs by decreasing the production of reactive oxygen species (ROS). Under normal conditions, ROS accumulation leads to apoptosis in both normal and cancer cells [75,76].

How do cancer cells develop drug resistance?

Cancer cells will become resistant to drugs by the mechanisms such as the inactivation of the drug, multi-drug resistance, cell death inhibition (apoptosis suppression), altering in the drug metabolism, epigenetic changing, changes in the drug targets, enhances DNA-repair and target gene amplification.

Are stem cells highly resistant to chemotherapy?

Human cancers emerge from cancer stem cells (CSCs), which are resistant to cancer chemotherapeutic agents, radiation, and cell death. Moreover, autophagy provides the cytoprotective effect which contributes to drug resistance in these cells.

What is cancer stem cell theory?

The stem cell theory of cancer proposes that among all cancerous cells, a few act as stem cells that reproduce themselves and sustain the cancer, much like normal stem cells normally renew and sustain our organs and tissues.

How do you make a drug resistant cancer cell line?

Start from LD50 dose of an anticancer drug(select marketed drug of same target) and then a stepwise increment of drug after every passage will lead to generate a drug-resistant cancer cell lines. If you are working with different Cancer cell lines.

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What type of cancer is resistant to chemotherapy?

Most advanced cancers, including ovarian cancers, eventually become resistant to therapy. Kaisa Lehti at the Karolinska Institute in Stockholm and her colleagues treated ovarian cancer cells with one of two platinum-based chemotherapies: cisplatin or carboplatin.

Can cancer cells evolve to resistance effective drugs?

Cancer cells can acquire resistance to targeted drugs when the genes encoding target proteins develop new mutations or change expression levels.

Can stem cells become cancerous?

What about the type of stem cells that more and more scientists are using instead of embryonic ones? Those are called induced pluripotent stem cells; they come from the cells of already-born people. Unfortunately, any such cells that grow in the lab long enough can accumulate cancer-causing mutations, Loring said.

Can cancer stem cells be killed?

At present, there are no drugs that can kill cancer stem cells, but people are looking for them,” Tillekeratne said. “A lot of drugs are discovered by serendipity. Sometimes in research if you get unexpected results, you welcome that because it opens up a new line of research.