Frequent question: What is extranodal disease in lymphoma?

Extranodal Lymphoma

What is extranodal lymphoma?

Extranodal lymphoma, by definition, involves sites other than lymph nodes, spleen, thymus and the pharyngeal lymphatic ring. Involvement of the spleen in HD is considered as nodal disease but in the case of non-Hodgkin lymphoma (NHL) the spleen is regarded as an extranodal site.

What causes extranodal lymphoma?

Gastric extranodal marginal zone lymphoma of MALT type. MALT lymphoma represents around 7% of all NHL in the Western world. At least one-third of them are a primary gastric lymphoma, which in approximately two-thirds of the cases is associated with a chronic Helicobacter pylori (H. pylori) infection (17).

What is considered extranodal?

(EK-struh-NOH-dul) Refers to an area or organ outside of the lymph nodes.

How do you treat extranodal marginal zone lymphoma?

Low-dose radiation therapy (4 Gy in 2 fractions) is used increasingly in the treatment of localized extranodal indolent lymphomas: although the progression-free survival (PFS) rate with 4 Gy is ∼75% at 5 years, local PFS remains inferior to that obtained with 24 Gy.

Is double hit lymphoma curable?

“The outcomes were far better than we saw with previous analyses,” he noted, adding fluorescence in situ hybridization (FISH) analysis identify double-hit lymphoma in otherwise low-risk patients, who have a greater than 50% chance of cure.

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What is difference between Hodgkin and non Hodgkin lymphoma?

The primary difference between these two categories of lymphatic cancer is the type of lymphocyte that is affected. Hodgkin lymphoma is marked by the presence of Reed-Sternberg cells, which a physician can identify using a microscope. In non-Hodgkin lymphoma, these cells are not present.

Can MALT lymphoma be cured?

The majority of cases with MALT lymphoma are cured by eradication therapy, but there are cases that need to be treated with rituximab alone or in combination with other drugs.

Does MALT lymphoma show in blood tests?

For MALT lymphomas of the stomach, this usually involves an endoscopy. Doctors will also test for the presence of the H. pylori bacteria in the stomach. Other tests that will need to be performed include blood tests, scans of the abdomen and chest, and also a bone marrow test.

What does MALT lymphoma look like?

MALT lymphoma affecting your tear ducts or tissues around your eye might cause symptoms such as redness of the eye, dark pink lumps inside your eyelid or the corners of your eye, double vision, a droopy eyelid or a bulging eye. Symptoms usually develop on one side but in around 1 in 10 cases, they can affect both eyes.

Is Waldeyer’s ring extranodal?

Waldeyer’s ring represents an extranodal but not an extralymphatic site. Waldeyer’s ring lymphoma accounts for approximately 50% of all extranodal non-Hodgkin’s malignant lymphomas in the head and neck; only the gastrointestinal tract is a more common site of extranodal non-Hodgkin’s lymphomas.

What is gastric lymphoma?

Summary. Primary gastric lymphoma is a general term for a type of cancer that originates within the stomach. Approximately 90 percent of patients of primary gastric lymphoma are either mucosa-associated lymphoid tissue (MALT) gastric lymphoma or diffuse large B-cell lymphoma (DLBCL) of the stomach.

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What are B symptoms?

The term “B symptoms” is used to refer to fever, drenching night sweats and loss of more than 10 percent of body weight over 6 months. B symptoms are significant to the prognosis and staging of the disease.