Should I take tamoxifen 5 or 10 years?
Currently, tamoxifen is usually given daily for five years after a cancer is treated. Doctors have known that five years is more effective than two, and that it reduces the rate of death from breast cancer by about a third in comparison to not taking it, and that it does so for 15 years after the diagnosis.
What happens after taking tamoxifen for 5 years?
Women who took tamoxifen for 5 years had a 17 percent lower risk of cancer recurrence and a 9 percent lower risk of death from breast cancer than women who took tamoxifen for only 2 years. They also had a 30 percent lower risk of developing cancer in the contralateral (other) breast.
Can you take tamoxifen for longer than 10 years?
A recent study published in the British Journal of Medicine indicated clear evidence that 10 years of tamoxifen therapy does reduce local recurrence and improve breast cancer-free survival. However, it also reported that extended use (10 years rather than five) was linked with a two-fold increase in endometrial cancer.
What is the success rate of tamoxifen?
The study found that patients with 5 years of tamoxifen treatment showed better disease free survival than patients with 10 years of treatment (82% vs 78%, P = . 03), and no statistically significant differences in survival rate were found between these 2 groups (94% vs 91%, P = . 07).
Is tamoxifen toxic to the liver?
Tamoxifen is a nonsteroidal antiestrogen that is widely used in the treatment and prevention of breast cancer. Long term tamoxifen therapy has been associated with development of fatty liver, steatohepatitis, cirrhosis, and rare instances of clinically apparent acute liver injury.
Is tamoxifen really necessary?
Tamoxifen is a highly effective breast cancer treatment. It may significantly lower your risk of breast cancer recurrence or invasive breast cancer. People who are at high risk for breast cancer may take tamoxifen to reduce their chances of getting the disease.
Do tamoxifen side effects get worse over time?
A German study suggests that women who expect to have more and more severe side effects before hormonal therapy starts do have worse side effects after 2 years of treatment.
Can you just stop tamoxifen?
Although tamoxifen is effective, many women stop taking it before they finish the full treatment course. Some may stop because of common side effects, such as hot flashes, vaginal dryness and mood swings. Others may worry about tamoxifen’s rare side effects, including blood clots and increased risk of uterine cancer.
What happens after taking tamoxifen for 10 years?
In rare cases, tamoxifen can cause dangerous blood clots. Tamoxifen also may increase the risk of endometrial cancer in some women. In this study, the researchers found that 10 years tamoxifen increased the risk of endometrial cancer compared to 5 years of tamoxifen.
How much does tamoxifen reduce the risk of recurrence?
Doctors have long known that five years of tamoxifen reduces recurrence by about half during treatment and by nearly a third over the next five years. Aromatase inhibitors, which work only in postmenopausal women, are even more effective than tamoxifen at reducing recurrence and death from breast cancer.
What is the best time of day to take tamoxifen?
Tamoxifen may be taken at any time of the day but should be taken at the same time each day. it is within 12 hours of the missed dose. If it is over 12 hours since your missed dose, skip the missed dose and go back to your usual dosing times.
Can I drink green tea while taking tamoxifen?
The combination of tamoxifen with green tea catechins could enhance its action in ER-negative breast cancer. In addition, such a combination could allow a dosage reduction of breast endocrine treatment in ER-positive breast cancer and in breast cancer chemoprophylaxis, leading to an amelioration of the safety profile.
What are the long term effects of tamoxifen?
Tamoxifen can have side effects, including hot flashes, fatigue, and an increased risk of blood clots and endometrial cancer. But there was no substantial increase in serious side effects, including endometrial cancer incidence or death, in women who took tamoxifen for the longer period, Gray reported.
Can tamoxifen affect your eyes?
The usual daily dose of tamoxifen is 20-40 mgs. Ocular side effects are relatively uncommon and are usually associated with higher doses. The ocular side effects are blurred vision, decreased visual acuity, vortex keratopathy, retinotoxicity, and bilateral optic neuritis.