Is giant cell tumor a sarcoma?

What is giant cell sarcoma?

A giant cell tumor is a rare, aggressive non-cancerous tumor. It usually develops near a joint at the end of the bone. Most occur in the long bones of the legs and arms. Giant cell tumors most often occur in young adults when skeletal bone growth is complete. The exact cause of giant cell tumors remains unknown.

What is a giant cell tumor made of?

A giant cell tumor is one that is made up of a large number of benign (non-cancerous) cells that form an aggressive tumor—usually near the end of the bone near a joint.

What percentage of giant cell tumor is malignant?

We identified 4 large series of patients with malignant giant cell tumor of bone that provided data on 2315 patients with giant cell tumor of bone. Across these studies, the cumulative incidence of malignancy was 4.0%; the cumulative incidence of primary malignancy was 1.6% compared with 2.4% for secondary malignancy.

What do giant cell tumors feel like?

A giant cell tumor is a rare, aggressive, noncancer tumor. It often grows near a joint at the end of the bone. Most occur in the long bones of the legs and arms. Symptoms may include joint pain, swelling, and limited movement.

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What do giant cells indicate?

Giant cells are formed by fusion of various cells such as macrophage, epithelioid cells, monocytes, etc., These are multi-nucleated,[1] large in size, and most of the times present at the site of chronic inflammation and other granulomatous conditions.

How fast does giant cell tumor grow?

Giant cell tumor of bone (GCTB) in skeletally immature patients is rare, and little is known regarding how fast GCTB can grow. We report a case of a 10-year-old skeletally immature girl with pathologically proven GCTB with obvious growth plate invasion that showed surprisingly rapid growth over only 14 days.

Do giant cell tumors metastasize?

Giant cell tumors of the bone are benign but locally aggressive, and they rarely metastasize to the lungs. The purpose of this study was to retrospectively review the clinical presentation, long-term outcomes, and treatment of pulmonary metastasis of these tumors.

Are giant cell tumor benign or malignant?

Most giant cell tumors occur at the ends of the long bones of the arms and legs, near a joint (such as the knee, wrist, hip, or shoulder). Most are benign (not cancer) but some are malignant (cancer). Giant cell tumors usually occur in young and middle-aged adults. Also called GCT.

How often do giant cell tumors come back?

Clinically, GCT presents as a benign but often aggressive lesion with a tendency toward local recurrence. Depending on the type of treatment and the local presentation of the tumor, recurrence rates range from 0% to 65% (Table 1) [1, 3, 5, 6, 15, 20, 25, 26, 29, 31, 37, 38, 40, 43, 50].

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What happens during tumor?

In general, tumors occur when cells divide and grow excessively in the body. Normally, the body controls cell growth and division. New cells are created to replace older ones or to perform new functions. Cells that are damaged or no longer needed die to make room for healthy replacements.

What is giant cell granuloma?

Giant cell granuloma (GCG) is an uncommon, benign, proliferative, intraosseous lesion representing < 7% of all benign jaw lesions. The etiology is unknown, but is thought to be a reactive process, possibly secondary to trauma or inflammation; however, some believe it is a benign neoplasm.

What does Chondroma mean?

(kon-DROH-muh) A rare, slow-growing tumor that is made up of cartilage and forms on or in bones or soft tissue. It is not cancer. The tumor usually occurs in the hands or feet, but it may also occur in the upper arm, thigh, collarbone, ribs, pelvis, spine, skull, and nasal sinuses.