What is luminal A breast cancer?


How is luminal A breast cancer treated?

When you are diagnosed with luminal A breast cancer, you will first have surgery to remove any cancer tumors in your breast. You may have a lumpectomy, when a surgeon removes just the lump or tumor, or a mastectomy, when your entire breast is removed. After you’ve healed from surgery, you may have radiation therapy.

What is prognosis for luminal A breast cancer?

Moreover, the two ER + breast cancer subtypes, luminal A and luminal B, are linked with a good prognosis and excellent long-term survival (approximately 80%–85% 5-year survival), whereas the ER negative subtypes (HER2 + and basal-like) are challenging to manage and are linked with poor prognosis (approximately 50%–60% …

Can luminal A be Grade 3?

Grade 3 tumors were detected in 18.0% of luminal A tumors, 58.9% of luminal B (HER2-), 75.4% of luminal B (HER2+), 92.7% of HER2, and 85.1% of basal-like tumors.

What percentage of breast cancer are luminal A?

In the United States, luminal A accounts for 73 percent of breast cancer cases, luminal B for 11 percent, triple negative for 12 percent and HER2-enriched for about 4 percent, according to the American Cancer Society.

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Can you live 20 years with breast cancer?

Since the hazard rate associated with inflammatory breast cancer shows a sharp peak within the first 2 years and a rapid reduction in risk in subsequent years, it is highly likely that the great majority of patients alive 20 years after diagnosis are cured.

Does luminal A breast cancer need chemotherapy?

suggested that luminal A requires chemotherapy only when the number of positive lymph nodes is ≥ 4 [11]. The National Comprehensive Cancer Network guidelines recommend that patients with luminal A breast cancer and patients with positive lymph nodes should receive chemotherapy regardless of the number of nodes [12].

Is grade 2 breast cancer luminal A or B?

Luminal A breast cancers are likely to benefit from hormone therapy and may also benefit from chemotherapy. Group 2 (luminal B). This type includes tumors that are ER positive, PR negative and HER2 positive.

Why are lobular cancers sneaky?

Instead of clustering together, lobular cells spread out single file like tree branches or spider webs or mesh, which explains why surgeons and oncologists often refer to it as “sneaky” or “insidious.” Because the cells don’t stick together well, there’s often no lump, making it harder for women to find during self-

Which breast cancer subtype has the best prognosis?

Luminal A cancers are low-grade, tend to grow slowly and have the best prognosis. Luminal B breast cancer is hormone-receptor positive (estrogen-receptor and/or progesterone-receptor positive), and either HER2 positive or HER2 negative with high levels of Ki-67.

What does HER2 mean?

HER2-positive breast cancer is a breast cancer that tests positive for a protein called human epidermal growth factor receptor 2 (HER2). This protein promotes the growth of cancer cells.

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What is HER2-positive?

HER2 is a growth-promoting protein on the outside of all breast cells. Breast cancer cells with higher than normal levels of HER2 are called HER2-positive. These cancers tend to grow and spread faster than other breast cancers, but are much more likely to respond to treatment with drugs that target the HER2 protein.

What is the most aggressive subtype of breast cancer?

Triple negative breast cancer (TNBC) is a more aggressive subtype of breast cancer and is characteristic of the absence of the expressions of estrogen receptor, progesterone receptor, and human epithelial growth factor receptor 2 in breast tumor tissues.

Which of the following is the most common histologic type of breast cancer?

The major invasive tumor types include infiltrating ductal, invasive lobular, ductal/lobular, mucinous (colloid), tubular, medullary and papillary carcinomas (Fig. 1). Of these, infiltrating ductal carcinoma (IDC) is, by far, the most common subtype accounting for 70–80% of all invasive lesions.