MANAGEMENT OF PERSISTENT OR RECURRENT MEDULLARY THYROID CARCINOMA
Is medullary carcinoma curable?
Together, you and your doctor will develop a treatment plan for medullary carcinoma. Some doctors feel that a true medullary carcinoma may only require surgery without any additional (or adjuvant) treatments, such as chemotherapy or radiation therapy.
How does medullary carcinoma start?
Medullary thyroid cancer starts as a growth of abnormal cancer cells within the thyroid. These special cells are the parafollicular C cells. In the hereditary form of medullary thyroid cancer, the growth of these cells is due to a mutation in the RET gene which was inherited.
Is medullary carcinoma aggressive?
Medullary thyroid cancer is a rare aggressive type of thyroid neoplasia. Significant predictors for MTC are age, gender, clinical presentation, TNM stage, distant metastases and extent of thyroidectomy.
What clinical management or treatment is suggested for MTC?
Doxorubicin (Adriamycin) and dacarbazine (DTIC) are the two agents with the most extensive track record, and dacarbazine is currently recommended as a treatment option for patients with disseminated, symptomatic disease. Doxorubicin was first tested in MTC patients in the 1970s.
How is medullary carcinoma diagnosed?
The Diagnosis of Medullary Thyroid Cancer is Made by Fine Needle Aspiration (FNA) Biopsy
- This type of biopsy can usually be done in your doctor’s office or clinic.
- Before the biopsy, local anesthesia (numbing medicine) may be injected into the skin over the thyroid nodule.
How common is medullary thyroid carcinoma?
How common is medullary thyroid cancer? Thyroid cancer is fairly common. There are four different types of thyroid cancers and MTC is the rarest type making up 3% to 4% of all thyroid cancers. About 1,000 people are diagnosed with MTC each year in the U.S.
What does medullary carcinoma mean?
Medullary carcinoma is defined in the WHO classification of breast tumors as a “well circumscribed carcinoma composed of poorly differentiated cells with scant stroma and prominent lymphoid infiltration.”
Does medullary carcinoma cause hyperthyroidism?
Medullary thyroid carcinoma (MTC) has been rarely described in association with Graves’ disease or other forms of hyperthyroidism. To our knowledge, only 14 cases have been described in which MTC was associated with hyperthyroidism.
Is medullary carcinoma of the thyroid hereditary?
Familial medullary thyroid cancer is inherited in a dominant way, which means a patient with the gene mutation for medullary thyroid cancer will have a 50% chance of passing it on to their offspring.
When is a tumor termed medullary?
Medullary carcinoma may refer to one of several different tumors of epithelial origin. As the term “medulla” is a generic anatomic descriptor for the mid-layer of various organ tissues, a medullary tumor usually arises from the “mid-layer tissues” of the relevant organ.
What is medullary carcinoma of the breast?
Medullary carcinoma of the breast is a subtype of invasive ductal carcinoma. It is a type of breast cancer that begins in the milk ducts. This breast cancer is named because the tumor resembles the part of the brain known as the medulla.