Why are bisphosphonates used in breast cancer?


How do bisphosphonates work in breast cancer?

Bisphosphonates slow down or prevent bone damage. You may hear bisphosphonates called bone-hardening or bone-strengthening treatment. Research has shown bisphosphonates may reduce the risk of breast cancer spreading to the bones and elsewhere in the body in post-menopausal women being treated for primary breast cancer.

Should I take bisphosphonates for breast cancer?

If you have early breast cancer, bisphosphonates can sometimes lower the risk of it spreading to the bone. This is called adjuvant treatment. You have bisphosphonates for 3 to 5 years.

Is bisphosphonate a chemotherapy?

The use of bisphosphonates to prevent bone metastases remains experimental. Last, bisphosphonates in addition to chemotherapy are superior to chemotherapy alone in patients with stages II and III multiple myeloma and can reduce the skeletal morbidity rate by approximately one half.

Why are bisphosphonates prescribed?

Bisphosphonates can be used to reduce the risk of hip and spine fractures in osteoporosis. They may also be used, at different doses, to treat Paget’s disease of bone. Bisphosphonates can be taken by mouth (orally), through a drip (intravenous infusion) or by injection.

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Can bisphosphonates stop cancer?

Bisphosphonate treatment can stop some types of cancer from spreading into the bone for some people. Studies have also shown that bisphosphonates can help some people with breast cancer and myeloma to live longer. Bisphosphonates might also help to: prevent or control bone thinning (osteoporosis)

Do bisphosphonates cause cancer?

Our findings indicate that bisphosphonates do not appear to increase cancer risk. Although reductions in breast and colorectal cancer incidence were observed in bisphosphonate users it is unclear, particularly for breast cancer, to what extent confounding by low bone density may explain the association.

Are bisphosphonates worth taking?

The higher your fracture risk, the more likely it is that bisphosphonates can help prevent a fracture. The lower your fracture risk, the less likely it is that these medicines can help prevent a fracture. If you have osteoporosis or you have had a fracture, taking bisphosphonates lowers your risk of a fracture.

How long do bisphosphonates stay in the body?

An FDA review of clinical studies measuring the effectiveness of long-term bisphosphonates use shows that some patients may be able to stop using bisphosphonates after three to five years and still continue to benefit from their use, says Marcea Whitaker, M.D., a medical officer at FDA’s Center for Drug Evaluation and …

What is the most common side effect of bisphosphonate?

The most common side effects of bisphosphonates are stomach irritation and heartburn, but these problems are often avoided by taking the medication correctly. Other common side effects include: Bone or joint pain, or generalized pain. Muscle cramps or aches.

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Do bisphosphonates weaken your immune system?

This work suggests that bisphosphonates have the potential to depress the innate immune system for a prolonged time, possibly contributing to the pathogenesis of BRONJ.

Can bisphosphonates cause hair loss?

Alopecia is an adverse drug reaction which is labeled for all statins. Alopecia is disproportionally associated with alendronate and risedronate in both the Lareb database and in the database of the WHO. Lareb received 53 reports of alopecia associated with the treatment with bisphosphonates.

Do bisphosphonates affect immune system?

Bisphosphonates are well tolerated with chronic administration and have very few adverse effects. Research suggests that these medications can stimulate the immune system.

Who should avoid bisphosphonates?

Clinicians should avoid oral bisphosphonates in patients who are at a higher risk of these gastrointestinal adverse effects, including those who are not able to sit upright for at least 30 minutes after taking the bisphosphonate, and patients with esophageal disorders such as achalasia, esophageal stricture, Barrett’s …

Which bisphosphonate is safest?

64–66,71,72 Recent publications indicate that the use of oral bisphosphonates (alendronate and risedronate) may be safe and effective in patients with glomerular filtration rates less than 30 mL/min.

What are the risks of taking bisphosphonates?

Side effects for all the bisphosphonates (alendronate, ibandronate, risedronate and zoledronic acid) may include bone, joint or muscle pain. Side effects of the oral tablets may include nausea, difficulty swallowing, heartburn, irritation of the esophagus (tube connecting the throat to the stomach) and gastric ulcer.