Why is first morning specimen unacceptable for urine cytology?

Why is the first morning urine specimen not the ideal specimen for cytology studies?

Because the urine from your first morning urination remains in your bladder for many hours through the night, the cells may degrade and not be useful for urine cytology.

Does a urine culture requires a first morning urine specimen?

Urine values vary considerably during a 24-hour period, and most test methods are based on normal values for first morning samples. The first urine voided in the morning is preferred because it has a more uniform volume and concentration and a lower pH, which helps preserve the formed elements.

Why is the morning specimen at the end of a 24-hour collection so important?

The first voided morning specimen is particularly valuable because it is more concentrated and abnormalities are easier to detect. … A 24-hour urine specimen is an extremely important diagnostic test because it reveals how the kidney adjusts to changing physiologic needs over a long period.

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Why must a 24-hour period sample of urine be used for examination if a detailed composition is to be determined?

Why might I need a 24-hour urine collection? A 24-hour urine collection helps diagnose kidney problems. It is often done to see how much creatinine clears through the kidneys. It’s also done to measure protein, hormones, minerals, and other chemical compounds.

What does a positive urine cytology mean?

This indicates that some abnormalities were found in your urine sample cells, but they weren’t abnormal enough to be considered cancer. Suspicious. The urine cells were abnormal and might be cancerous. Positive. A positive result indicates that cancer cells were found in your urine.

How long can urine sit before being tested?

Storing a urine sample

Do not keep it for longer than 24 hours. The bacteria in the urine sample can multiply if it is not kept in a fridge. If this happens, it could affect the test results.

Why urine sample should not be collected from urine bag?

Due to the high contamination rates, and the less than favourable risk profile, the American Academy of Pediatrics concluded that bag urine specimens are not useful for diagnosing UTI and should always be followed up with another method in young children to confirm the diagnosis.

What urine specimen has the highest concentration of hCG?

The urine specimen must be collected in a clean, dry container. Specimens collected at any time are acceptable, however, the first morning urine generally contains the highest concentration of hCG.

What test requires a clean catch midstream specimen?

A clean catch urine sample or specimen is one of the least invasive procedures for a urine culture or urinalysis. The clean catch method aims to prevent bacteria from the skin of the penis or vagina from contaminating the urine specimen.

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What can you not do on a 24-hour urine collection?

For 24 hours prior to collecting the specimen, you should avoid strenuous exercise as well as the following substances and drugs:

  • Acetaminophen.
  • Alcohol.
  • Antihistamines.
  • Aspirin.
  • Caffeine.
  • Vitamin B.

How much urine is needed for 24-hour collection?

The normal range for 24-hour urine volume is 800 to 2,000 milliliters per day (with a normal fluid intake of about 2 liters per day).

Does 24-hour urine collection need to be refrigerated?

If you leave your home or hospital room during your 24-hour collection period, take the urinal or collection hat and labeled container with you. Store the labeled container at room temperature. You don’t have to refrigerate it.