What is Mullerian malignancy?
A malignant mixed müllerian tumor (MMMT), also called a carcinosarcoma, is a type of cancer that contains two types of cancer cells – carcinoma and sarcoma cells. These tumors usually develop in tissues of the female genital tract and are associated with a poor outcome.
What is Mullerian origin cancer?
Müllerian epithelial cancers include all epithelial cancers traditionally referred to as ovarian carcinomas in addition to those from organs derived from the Müllerian ducts such as uterus and cervix.
What is high grade Mullerian carcinoma?
High-grade serous carcinoma, traditionally presumed to arise within Müllerian inclusion cysts of the ovarian surface, cortex and peritoneum, has recently been linked to the distal fallopian tube.
What is the meaning of Mullerian?
Medical Definition of Müllerian duct
: either of a pair of embryonic ducts parallel to the Wolffian ducts and giving rise in the female to the fallopian tubes, uterus, cervix, and upper portion of the vagina.
What is the Mullerian?
The müllerian ducts are the primordial anlage of the female reproductive tract. They differentiate to form the fallopian tubes, uterus, the uterine cervix, and the superior aspect of the vagina. A wide variety of malformations can occur when this system is disrupted.
What does Mullerian origin mean?
Adenocarcinoma of Mullerian origin, previously, known as ‘mesothelioma of pelvic origin‘, is a rare primary malignancy of the peritoneum . It is frequently found identical to papillary serous adenocarcinoma of the ovary, hence, also referred to as extraovarian peritoneal serous papillary carcinoma.
What are the Mullerian ducts?
The Müllerian duct (MD) is the embryonic structure that develops into the female reproductive tract (FRT), including the oviduct, uterus, cervix and upper vagina. The FRT has essential functions in mammals, providing the site of fertilization, embryo implantation and fetal development.
Is ovarian Carcinosarcoma genetic?
Ovarian carcinosarcoma is not thought to be due to an inherited gene mutation . We are aware of one report of a woman with a BRCA2 gene mutation who developed ovarian carcinosarcoma.
Is ovarian Carcinosarcoma rare?
Ovarian carcinosarcomas (OCS), also called malignant mixed müllerian tumor (MMMT), are rare and aggressive tumors, accounting for less than 1% of all ovarian malignancies.
How aggressive is Carcinosarcoma?
Introduction. Carcinosarcoma of the uterus (also known as malignant mixed Mullerian tumor, MMMT) is a highly aggressive form of uterine cancer. Even though it constitutes about 3-4% of uterine malignancy overall, it accounts for a disproportionate percentage of mortality associated with uterine malignancy.
What is ovarian clear cell carcinoma?
Ovarian clear cell carcinoma (OCCC) is a special pathological type of epithelial ovarian carcinoma (EOC). We conducted this research to investigate the clinical characteristics and outcomes of OCCC and to provide additional supporting evidence to aid in the clinical diagnosis and management.
How fast does high grade serous carcinoma grow?
Recent research has found that high-grade serous cancers that begin in the fallopian tubes take on average 6.5 years to progress to the ovaries, and then spreads to other areas quickly. These advanced carcinomas typically spread to the peritoneum first (lining of the organs of the pelvis and abdomen).
Is high grade serous carcinoma hereditary?
These molecular findings support to the role of TP53 mutation as an early event in the pathogenesis of high-grade serous carcinoma and that the origin for some tumors is the surface epithelium or epithelial inclusions of the ovary. Parenthetically, 10% of ovarian carcinomas are hereditary.