Best answer: Why is chemotherapy drug dosing important?

Why is chemo dosed on BSA?

Dosing based on body surface area (BSA) is generally used in an effort to normalize drug concentrations. This is because it is well recognized that measures of many physiologic parameters that are responsible for drug disposition, including renal function and energy expenditure, can be normalized by use of BSA.

How are most chemo drugs dosed?

In an attempt to minimize interindividual variation, dosing for most anticancer agents has generally been normalized using mg of drug per m2 of body surface area (BSA), which is calculated using a patient’s height and weight.

How are chemotherapy doses calculated?

The majority of cytotoxic chemotherapy doses are individualised for each patient and most commonly calculated based on the patient’s body surface area (BSA), renal function or weight. BSA has been shown to correlate with cardiac output, total blood volume as well as renal function.

Why is it important to treat a cancer with multiple drugs?

Combination chemotherapy is the use of more than one medication at a time to treat cancer. Since chemotherapy drugs affect cancer cells at different points in the cell cycle, using a combination of drugs increases the chance that all of the cancer cells will be eliminated.

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How many rounds of chemo can a person have?

You may need four to eight cycles to treat your cancer. A series of cycles is called a course. Your course can take 3 to 6 months to complete. And you may need more than one course of chemo to beat the cancer.

What side effects does chemotherapy have?

Here’s a list of many of the common side effects, but it’s unlikely you’ll have all of these.

  • Tiredness. Tiredness (fatigue) is one of the most common side effects of chemotherapy. …
  • Feeling and being sick. …
  • Hair loss. …
  • Infections. …
  • Anaemia. …
  • Bruising and bleeding. …
  • Sore mouth. …
  • Loss of appetite.

What are the signs that chemo is working?

Complete response – all of the cancer or tumor disappears; there is no evidence of disease. A tumor marker (if applicable) may fall within the normal range. Partial response – the cancer has shrunk by a percentage but disease remains. A tumor marker (if applicable) may have fallen but evidence of disease remains.

Does chemotherapy make you lose your hair?

Chemotherapy drugs are powerful medications that attack rapidly growing cancer cells. Unfortunately, these drugs also attack other rapidly growing cells in your body — including those in your hair roots. Chemotherapy may cause hair loss all over your body — not just on your scalp.

What drugs are in chemo?

Chemotherapy Medicines

  • Abraxane (chemical name: albumin-bound or nab-paclitaxel)
  • Adriamycin (chemical name: doxorubicin)
  • carboplatin (brand name: Paraplatin)
  • Cytoxan (chemical name: cyclophosphamide)
  • daunorubicin (brand names: Cerubidine, DaunoXome)
  • Doxil (chemical name: doxorubicin)
  • Ellence (chemical name: epirubicin)
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How many chemo cycles are normal?

During a course of treatment, you usually have around 4 to 8 cycles of treatment. A cycle is the time between one round of treatment until the start of the next. After each round of treatment you have a break, to allow your body to recover.

How long does chemo take to shrink a tumor?

In general, chemotherapy can take about 3 to 6 months to complete. It may take more or less time, depending on the type of chemo and the stage of your condition. It’s also broken down into cycles, which last 2 to 6 weeks each.

What is chemotherapy process?

Overview. Chemotherapy is a drug treatment that uses powerful chemicals to kill fast-growing cells in your body. Chemotherapy is most often used to treat cancer, since cancer cells grow and multiply much more quickly than most cells in the body. Many different chemotherapy drugs are available.