Frequent question: Can tamoxifen cause chemo brain?

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Which drugs cause chemo brain?

Summary: In a new study explaining the cellular mechanisms behind cognitive impairment from chemotherapy, scientists have demonstrated that a widely used chemotherapy drug, methotrexate, causes a complex set of problems in three major cell types within the brain’s white matter.

Can tamoxifen cause memory problems?

One of the most common side effects mentioned was “brain fog” – memory loss and concentration issues brought on by use of tamoxifen or aromatase inhibitors.

Does tamoxifen affect your brain?

Tamoxifen, one of the most widely used anti-cancer agents, is toxic to certain cells of the brain and the central nervous system, which may explain the phenomenon of mental fogginess that occurs in some women who take it.

Can tamoxifen cause dementia?

Patients with breast cancer exhibited a similar risk of developing dementia. Tamoxifen users exhibited a significant 17% lower risk of dementia compared with those not using tamoxifen.

What’s the worst chemotherapy drug?

Doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented. It can kill cancer cells at every point in their life cycle, and it’s used to treat a wide variety of cancers. Unfortunately, the drug can also damage heart cells, so a patient can’t take it indefinitely.

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Does chemo shorten life expectancy?

During the 3 decades, the proportion of survivors treated with chemotherapy alone increased (from 18% in 1970-1979 to 54% in 1990-1999), and the life expectancy gap in this chemotherapy-alone group decreased from 11.0 years (95% UI, 9.0-13.1 years) to 6.0 years (95% UI, 4.5-7.6 years).

Does tamoxifen make you feel crazy?

TUESDAY, Sept. 17 (HealthDay News) — Some women who take tamoxifen to treat or prevent breast cancer report experiencing a mental fogginess while on the drug, and researchers have now confirmed that there’s a biological basis for those symptoms.

Does tamoxifen affect your eyesight?

Extensive retinal lesions and macular edema with visual impairment have been reported in a few patients receiving high-dose tamoxifen. Less extensive retinal changes may occur in patients receiving low doses for long periods, and isolated retinal crystals may be observed in patients without visual symptoms.

How bad are tamoxifen side effects?

Side effects of tamoxifen may include: Menopause-like symptoms, including hot flashes, night sweats and vaginal dryness. Weight gain (more common) or fluid retention (edema). Irregular or loss of menstrual periods.

Does tamoxifen interfere with sleep?

Background: Insomnia is a frequent adverse effect reported by women taking tamoxifen, an estradiol receptor-antagonist, for breast cancer.

Why you should not take tamoxifen?

Tamoxifen may cause hot flashes and increase the risk of blood clots and stroke. Aromatase inhibitors may cause muscle and joint aches and pains. Less common but more severe side effects of aromatase inhibitors are heart problems, osteoporosis, and broken bones.

Is tamoxifen bad for your liver?

Tamoxifen is a nonsteroidal antiestrogen that is widely used in the treatment and prevention of breast cancer. Long term tamoxifen therapy has been associated with development of fatty liver, steatohepatitis, cirrhosis, and rare instances of clinically apparent acute liver injury.

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What are the long term effects of tamoxifen?

Tamoxifen can have side effects, including hot flashes, fatigue, and an increased risk of blood clots and endometrial cancer. But there was no substantial increase in serious side effects, including endometrial cancer incidence or death, in women who took tamoxifen for the longer period, Gray reported.

What not eat or drink when taking tamoxifen?

The foods of most concern for women taking tamoxifen are grapefruit and tangerines. Grapefruit is well-known to interfere with numerous medications. Many drug-interaction resources specifically advise that women taking tamoxifen avoid grapefruit.

What happens when you stop tamoxifen?

Blood clots in your veins or lungs.

These can occur for up to 2–3 months after you stop taking tamoxifen. Symptoms can include: sudden chest pain. shortness of breath.