How long can you take letrozole for metastatic cancer?

Does letrozole stop cancer spreading?

Drugs such as everolimus and letrozole have been shown to be effective at stopping tumor growth either by killing the cells, by stopping them from dividing, or by stopping them from spreading.

What happens after 5 years of taking letrozole?

An additional 5 years of letrozole resulted in a 34% reduction in the risk of recurrence, with no worsening of quality of life. No new side effects or emergent symptoms were reported with extending letrozole for another 5 years.

How effective is letrozole for metastatic breast cancer?

Letrozole treatment resulted in a median PFS of 16.8 months (95% confidence interval [CI], 9.8 to 23.8) and a median OS of 56.4 months (95% CI, 38.1 to 74.7). The ORR was 36.9% for the 84 patients with measurable lesions.

Can I take letrozole more than 10 years?

MA-17R study

However, extending letrozole therapy to 10 years came with side effects. Women who took letrozole had more bone pain, bone fractures, and osteoporosis diagnoses than women who took placebo.

Can I take vitamin D with letrozole?

No interactions were found between letrozole and Vitamin D3. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

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What is the success rate of letrozole?

In the intention-to-treat analysis, women who received letrozole alone had a disease-free survival rate of 73.8 percent at 8 years, compared with a rate of 70.4 percent for women who received tamoxifen alone.

Does taking letrozole affect your immune system?

Taking hormone therapy does not affect your immune system. Hormone therapies, including tamoxifen, letrozole, anastrozole, exemestane and goserelin, do not affect your risk of getting coronavirus or of becoming seriously ill if you do get it.

Do you gain weight on letrozole?

Weight gain is one of the occasional side effects that can occur when taking letrozole but if you are finding it difficult to control then it may be worth getting in touch with your doctor to let them know.

Is letrozole worth taking?

Letrozole helps stop your breast cancer coming back. By taking this medicine for 5 years (or sometimes up to 10 years), you have a better chance of being alive 15 years after your breast cancer was first diagnosed. Your specialist will be able to explain the benefits and risks of taking letrozole.

What are the worst side effects of letrozole?

Side effects of letrozole (Femara)

  • aching or pain in the joints or muscles.
  • menopausal symptoms.
  • low mood and depression.
  • difficulty sleeping.
  • fatigue.
  • osteoporosis.
  • high blood pressure and cholesterol.