What is the role of beta-catenin?
In the canonical Wnt cascade, β-catenin is the key effector responsible for transduction of the signal to the nucleus and it triggers transcription of Wnt-specific genes responsible for the control of cell fate decisions in many cells and tissues.
What genes does beta-catenin regulate?
β-catenin target genes have been implicated in regulating different cellular processes including proliferation (e.g., MYC, CCND1, PPARD), stem cell fate (ASCL2), survival (ABCB1, BIRC5), differentiation (ID2, ITF2, ENC1), migration (MMP7, MMP14), and angiogenesis (VEGF) [4–18].
What happens when there is too much beta-catenin?
We report here that overexpression of beta-catenin results in accumulation of p53, apparently through interference with its proteolytic degradation. This effect involves both Mdm2-dependent and -independent p53 degradation pathways, and is accompanied by augmented transcriptional activity of p53 in the affected cells.
Is beta catenin a coactivator?
Previous studies have shown that β-catenin activates TCF-mediated transcription in various cell lines (4). … 2B), further supporting the role of p300 as a coactivator for β-catenin/TCF-mediated transcription.
How do you lower catenin beta?
The modulators of β-catenin degradation
Efforts are made to activate kinase activity and thus to reduce the stability of β-catenin. Axin is an important protein in promoting β-catenin degradation. Tankyrase1/2 is a kinase destabilizing Axin, which is chosen as a target to reduce the accumulation of β-catenin.
What does beta catenin bind to?
β-Catenin interacts with the transcription factor, T-cell factor/lymphoid enhancer-binding factor, and regulates the transcription of various target genes associated with cell survival, proliferation, metastasis, and EMT . Honokiol has been examined to have inhibitory effects on β-catenin.
Where is B catenin found?
This protein is present in many types of cells and tissues, where it is primarily found at junctions that connect neighboring cells (adherens junctions). Beta-catenin plays an important role in sticking cells together (cell adhesion) and in communication between cells.
How is beta catenin degraded?
The Wnt/β-catenin pathway is highly regulated to insure the correct temporal and spatial activation of its target genes. … Ubiquitinated β-catenin is degraded by the proteasome. The molecular mechanisms that underlie several aspects of destruction complex function are poorly understood, particularly the role of APC.
What are Wnt responsive genes?
We define “direct Wnt targets” as genes whose regulatory DNA can be physically associated with T-cell factors (TCFs) or other transcription factors (TFs) and whose expression is modulated by the recruitment of β-catenin to regulatory chromatin by these TFs.
What is CTNNB1 syndrome?
CTNNB1 Syndrome is a severe neurodevelopmental disorder caused by disruption of chromosome 3p22. 1 of the CTNNB1 gene (Verhoeven et al. 2020). It is a recently discovered condition associated with developmental delay, intellectual disability and speech delay.