What are the side effects of platinum-based chemotherapy?
Other common and well-known side effects of platinum-based chemotherapy include nausea, vomiting, diarrhoea, stomatitis (inflammation of mouth and lips) pain, mucositis (painful inflammation and ulceration of mucous membranes lining the digestive tract), alopecia (hair loss), anorexia (loss of appetite), cachexia (loss …
Why is platinum used to treat cancer?
Platinum-based drugs are effective against cancer because at their centre is a platinum atom joined to two ammonion molecules and two chloride ions. The compound is negatively charged, but when it enters the cancer cell it becomes positively charged because the chloride ions are replaced by water molecules.
Which drugs are platinum-based chemotherapy?
Platinum-based anticancer drugs, including cisplatin, carboplatin, oxaliplatin, nedaplatin, and lobaplatin, are heavily applied in chemotherapy regimens. However, the intrinsic or acquired resistance severely limit the clinical application of platinum-based treatment.
What is the side effects of platinum?
Other common side effects include anaphylaxis, cytopenias (including leukopenia and neutropenia, thrombocytopenia, and anaemia), hepatotoxicity, ototoxicity, cardiotoxicity, nausea and vomiting, diarrhea, mucositis, stomatitis, pain, alopecia, anorexia, cachexia, and asthenia.
Do platinum chemo drugs cause hair loss?
The “normal” cells will grow back and be healthy but in the meantime, side effects occur. The “normal” cells most commonly affected by chemotherapy are the blood cells, the cells in the mouth, stomach and bowel, and the hair follicles; resulting in low blood counts, mouth sores, nausea, diarrhea, and/or hair loss.
Which chemo drugs make you lose hair?
Chemotherapy drugs that tend to cause hair loss include:
What is the most powerful chemotherapy?
Doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented. It can kill cancer cells at every point in their life cycle, and it’s used to treat a wide variety of cancers.
What do platinum drugs do?
Doctors use platinum drugs to treat many kinds of cancer, both alone and in combination with other drugs. Cisplatin, the oldest, has been approved as a cancer treatment since 1978. In the U.S., two other platinum-containing molecules are also approved cancer drugs: carboplatin and oxaliplatin.
How does platinum chemo work?
Platinum-Based Drugs (Cisplatin, Carboplatin)
These drugs form highly reactive platinum complexes that bind and crosslink DNA, a double-stranded molecule inside the nucleus of the cell that controls cellular activity. The chemical crosslinking within the DNA prevents cancer cells from growing and causes them to die.
Is pemetrexed platinum-based?
Single pemetrexed is noninferior to platinum-based pemetrexed doublet as first-line treatment on elderly Chinese patients with advanced nonsquamous nonsmall cell lung cancer.
What does platinum resistant mean?
Cancer that responds at first to treatment with drugs that contain the metal platinum, such as cisplatin and carboplatin, but then comes back within a certain period. For example, ovarian cancer that comes back within 6 months after treatment is considered platinum resistant.